Which is better Ursosan or Ursodez? What is the difference between them? Patient reviews. Release forms and prices

De Nol is a drug from the group of gastroprotectors (medicines that prevent the destruction of the gastric mucosa). The active ingredient is bismuth. This drug has the following effects: antibacterial (suppressing the growth and development of pathogenic microorganisms), gastroprotective and antiulcer.

Nolpaza - this drug is a representative of the group of proton pump inhibitors (blocking the production of hydrochloric acid by the stomach glands). Active ingredient: pantaprazole. The medicinal substance blocks the excessive production of hydrochloric acid by the endocrine glands, thereby protecting the gastric mucosa from destruction.

Indications

De-Nol

• Chronic and acute stage of gastric and duodenal ulcers;
• As the main drug in antibacterial therapy, to destroy Helicobacter pylori (a bacterium that is the main cause of gastric ulcers);
• Chronic gastritis (inflammation of the walls of the stomach) and gastroduodenitis (inflammatory processes in the mucous membrane of the duodenum);
• For irritable bowel syndrome (dyspeptic symptoms in the form of diarrhea, nausea and stomach pain, for no apparent reason).

Nolpaza

• Acute stages of gastric and duodenal ulcers;
• Gastritis caused by taking non-steroidal anti-inflammatory drugs (NSAIDs);
• Gastroesophageal reflux disease (GERD) is a regularly recurring, spontaneous reflux of stomach contents into the esophagus;
• Syndromes and conditions associated with high acidity in the stomach.

Omeprazole and de-nol - can they be taken at the same time (compatibility)

Often, a gastroenterologist prescribes taking De-Nol and Omez at the same time. These drugs belong to different pharmacological groups, their actions complement each other. How to take De-Nol with Omez?

It is very important to take these medications correctly, as taking them incorrectly can result in less effective treatment. Therefore, you should definitely check with your doctor about how to properly take De-Nol and Omez together.

The dosage of the drug is determined by the doctor, who must also recommend a treatment regimen. The standard treatment regimen with De-Nol and Omez is as follows:

• In the morning on an empty stomach you need to take an Omez capsule;
• after half an hour you need to take a De-Nol tablet;
• in another half hour you will be able to have breakfast;
• the second and third De-Nol tablets must be taken half an hour before lunch and dinner, respectively;
• The fourth De-Nol tablet is taken at night.

When a Helicobacter pylori infection is detected, antibiotics are included in the treatment regimen with Omez and De-Nol. As a rule, two antibacterial drugs are prescribed. The course of treatment with antibiotics is 7-10 days, it is necessary to take De-Nol and Omez longer, the course of treatment is 1-2 months.

Gastritis and stomach ulcers are the most common diseases of the digestive system. There are several reasons for their occurrence, but the main one is the imbalance between the aggressive acidic environment of the gastric juice and the protective mechanism of its mucous membrane.

Digestive juice contains hydrochloric acid and the enzyme pepsin. Both components play an important role in the digestion process. It is under their influence that food breaks down into its constituent organic compounds. But the lining of the stomach is also affected.

How can you help the body protect the walls of the stomach from the destructive effects of digestive juices? For this purpose, there are a number of drugs that can reduce their aggressive effects. Such medications include De-Nol and Omeprazole.

Can they be used for the complex treatment of gastritis and gastric ulcers? Are there any contraindications to the use of these drugs? Can taking inhibitor drugs cause side effects?

One of the modern antisecretory drugs, Omeprazole, is widely used to treat gastric ulcers and other erosive and inflammatory disorders of the upper digestive tract. Its mechanism of action is based on the inhibitory properties of the biologically active substance omeprazole. It can suppress the formation of HCl in the stomach and reduce its activity.

Gastritis is a pathology in which inflammation develops in the stomach and is accompanied by increased or decreased levels of acid.

Omeza capsules are actively used by specialists in the complex therapy of gastritis, the development of which is provoked by the pathogenic bacterium Helicobacter.

The manufacturer of the drug indicates in the instructions the following contraindications:

• individual intolerance to the components included in the capsules;
• gestation period;
• young age.

After penetration into the stomach, the De-Nola tablet interacts with hydrochloric acid and creates a protective bar on the walls of the organ, thanks to which regeneration processes are accelerated.

Due to its excellent pharmacological properties, experts prescribe this medication to patients in order to prevent the development of ulcerative lesions and their subsequent degeneration into malignant neoplasms.

The manufacturer indicates as contraindications:

• individual intolerance to the components of the drug;
• period of gestation and breastfeeding;
• young age;
• acute or severe form of renal failure.

Also in the instructions for De-Nol, the manufacturer indicates that you need to take the tablets thirty minutes either before or after a meal. The duration of therapy does not exceed two months.

When treating chronic forms of gastritis, specialists often use a four-component drug therapy regimen.

When using a four-component regimen of drug therapy for gastritis, patients should take these medications in the following way:

• Omez capsules should be taken an hour before meals.
• De-Nola tablets should be taken thirty minutes after a meal.

If antibiotics are included in the drug therapy regimen, its duration is 14 days. In this case, patients should take Omez capsules 1-2 times a day, and De-Nola tablets up to 4 times a day.

Pathologies of the digestive system most often arise as a result of the simultaneous influence of several provoking factors. Only complex drug therapy can eliminate them. Omeprazole and De-Nol, taken together, effectively eliminate gastrointestinal problems.

Hydrochloric and bile acids, pepsin thoroughly digest ingested food products. However, these active ingredients of digestive juices act aggressively on the walls of the stomach.

Its mucous membrane is protected by a reliable defense mechanism. But when it fails, inflammation develops.

The most common pathologies of the gastrointestinal tract are erosions and ulcerative lesions of the stomach. There are medications that reduce the degree of aggressiveness of the acidic environment and suppress the proliferation of pathogenic flora. The most effective today are Omeprazole and De-Nol. The combination of these drugs from the group of gastroprotectors eliminates even severe gastrointestinal inflammation.

Omeprazole (Russia) is prescribed together with De-Nol (Netherlands) for acute forms of gastritis and ulcers, exacerbations of chronic gastrointestinal pathologies. These medications act on the affected organs of the gastrointestinal tract in different ways. The therapeutic effect of taking them together is much higher than when treating them separately.

However, De-Nol significantly weakens the effect of Omeprazole. Therefore, it is necessary to maintain a time interval between doses of drugs of 1-1.5 hours. You cannot prescribe treatment with them yourself. With a mild form of gastritis and a negative test for Helicobacter pylori, Omeprazole alone is most often sufficient. The decision to take these medications together should be made only by your doctor.

Both drugs are radically different in their composition. Omeprazole is the name of the drug and its active ingredient. The active compound of De-Nol is bismuth subcitrate in colloidal form. The therapeutic effect of each of these drugs also differs significantly.

Omeprazole is an antisecretory inhibitor. Within an hour, it penetrates into the cells that synthesize digestive juices, acting for about a day.

As the medicine accumulates, it suppresses the proton pump (an enzyme that produces hydrochloric acid), and the aggressiveness of the acidic environment decreases.

This significantly reduces the risk of reflux esophagitis and other complications. The maximum therapeutic effect occurs 3-4 days after the first day of taking the drug. At the end of the course of therapy, the production of digestive secretions is completely restored within 5-6 days.

Omeprazole is indicated for use in the following diseases:

• hyperacid gastritis (with increased acidity of gastric juice);
• stomach ulcer, duodenal ulcer;
• reflux esophagitis (inflammation of the walls of the esophagus due to repeated reflux of food masses from the stomach);
• Zollinger-Ellison syndrome (a condition with frequent diarrhea caused by a tumor of the pancreas or duodenum).

This drug has many analogues and synonyms. Sometimes, instead of cheap Russian Omeprazole, doctors prescribe more expensive imported Omez. Although their composition is identical, some gastroenterologists believe that the Indian remedy quickly relieves the symptoms of an acute disease. In addition, in their opinion, it is safer for renal and liver failure.

De-Nol has an even wider spectrum of pharmacological action. It is an antiseptic with a pronounced antibacterial effect on Helicobacter pylori.

The bismuth salt in the drug, which is toxic to pathogens, prevents them from developing resistance to the drug. At the same time, it neutralizes aggressive digestive acids.

Unlike Omeprazole, De-Nol is also active in the intestines. After all, the multiple bends of its thin and thick sections are localization sites that are comfortable for pathogenic flora. This is especially important when eliminating duodenal ulcers.

The drug also stimulates blood microcirculation in inflamed mucous membranes. Thanks to this, metabolism in cells improves. The walls of the affected organs heal faster. Another advantage of the drug is that it almost does not enter the general bloodstream.

Indications for use of De-Nol:

• stomach and duodenal ulcers caused by activation of Helicobacter pylori;
• exacerbation of chronic pathologies: gastritis, gastroduodenitis, ulcerative lesions;
• irritable bowel syndrome;
• dyspepsia (non-ulcer digestive disorder).

Standard scheme:

• Omeprazole – 1 tablet (20 mg) in the morning on an empty stomach or at night or twice a day, morning and evening
• De-Nol - 1 tablet (120 mg) every 1-1.5 hours.

For chronic pathologies caused by the proliferation of Helicobacter pylori, doctors select multicomponent regimens that include antimicrobial agents:

• Amoxicillin.
• Clarithromycin.
• Alpha Normixa (Rifaximin).
• Metronidazole, etc.

We must remember: only a gastroenterologist can prescribe an adequate treatment regimen. The maximum intake of De-Nol is no more than 2 months. Uncontrolled treatment with this drug is fraught with kidney damage, the development of tumors and their late detection.

These gastroprotectors cannot be used to treat:

• when hypersensitivity to drug ingredients or allergic reactions occurs;
• in the presence of severe renal and liver failure;
• if the patient is under 18 years of age;
• during pregnancy, breastfeeding.

Which is better, De Nol or Nolpaza?

There is no answer to this question. The named drugs, in addition to their relationship to different groups of medicinal substances, have a lot of other differences. De Nol effectively fights the causative agent of gastric and duodenal ulcers, the bacterium Helicobacter pylori. In addition to its antibacterial properties, it has an enveloping effect to protect the gastric mucosa.

Nolpaza, in turn, being a proton pump blocker, is effective for gastritis with high acidity and gastroesophageal reflux.

Which drug is better

Taking Omez or De-Nol - which is better for stomach diseases? It is impossible to give a definite answer to this question. Reviews about these drugs are good, but there are also people who are dissatisfied.

The fact is that De-Nol and Omez are drugs with different effects. The purpose of Omez is to reduce the production of hydrochloric acid, which negatively affects the walls of the stomach, and De-Nol performs a protective function and helps fight infections.

Gastritis and ulcers are the most common diseases of the digestive system. Not only older people, but also children face them. One of the reasons for the development of lesions is a violation of the acid-base balance, as well as the proliferation of bacteria. For treatment, doctors often prescribe Omeprazole and De-Nol. The drugs can be prescribed separately or simultaneously.

Contraindications

De-Nol and Nolpaza are contraindicated during pregnancy and breastfeeding. Nolpaza can be prescribed by a doctor if necessary and under supervision to a nursing woman, and the baby should be weaned from the breast and transferred to artificial nutrition for the duration of treatment.

Both drugs cannot be prescribed to patients with impaired renal function and individual intolerance to the drug or one of its components.

Nolpaza has an additional range of contraindications:

• Children and adolescents should not be prescribed medicine if they are under eighteen years of age;
• patients with liver failure should take the tablets with constant monitoring of liver enzyme levels to avoid cirrhosis or liver failure;
• for stomach and intestinal disorders that arise against the background of neuroses;
• people who have problems absorbing vitamin B12;
• patients with hereditary fructose intolerance.

In the presence of malignant oncological formations, a full examination should first be carried out to identify the cause of the disease and establish the correct diagnosis. The medicine can mask the underlying disease and its symptoms.

Doctors' opinion about Ursosan and Heptral

Bilan. V., therapist, candidate of medical sciences, Moscow

The drug "Ursosan" is most effective for diseases of the liver and gall bladder. I prescribe it to my patients during the period of diagnosing the gallbladder for the presence of pseudopolyps or real growths. "Ursosan" is able to dissolve stones (7-8 mm) in the bile ducts. In some patients, in addition to gallstones, a stomach ulcer is diagnosed. In this case, it is important not to complicate the situation and take the hepatoprotector with caution.

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Ursosan is available with a prescription, which must be written by the attending physician in Latin. Taking the drug as prescribed by your doctor minimizes the risk of adverse reactions. Some patients suffer from bouts of vomiting, diarrhea, and loss of a certain amount of hair. Allergies (itching, hyperemia) may occur.

Volodina Yu., gastroenterologist, Magnitogorsk

In recent years I have been actively prescribing this drug. The effectiveness of Heptral has been tested in practice. I prescribe the medicine to patients with alcoholic and non-alcoholic liver cirrhosis. "Heptral" can be prescribed for cirrhosis in the initial stages of the disease. At the beginning of treatment, you need to use an injection solution (intramuscular, intravenous). Injections need to be given over 6-7 days. Next, I recommend switching to the oral form of the medication.

One of the main disadvantages of the drug is the high price of the full course of therapy. I would like to note a fairly pronounced clinical effect. The medicine can be taken during the recovery period after gall bladder surgery.

Ursosan

The active substance of the drug is ursodeoxycholic acid.

Taking Ursosan provides the following positive changes:

1. - cells of the bile ducts and liver become more stable;
2. - cholesterol in the blood is normalized (due to a decrease in its absorption);
3. - the formation of cholesterol gallstones is blocked, and already formed stones are destroyed;
4. - a number of immune system receptors that recognize foreign microorganisms change. Due to this, the body’s immune system is significantly strengthened;
5. — connective tissue elements of the liver slow down their growth. This factor is especially relevant during inflammatory processes in the liver, which destroy organ tissue.

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"Ursosan" is prescribed in the following situations:

1. — presence of gallstones (tendency to their formation);
2. — all types of hepatitis (autoimmune, alcoholic, viral);
3. - all forms of liver cirrhosis (including Wilson-Konovalov pathology with sclerosing cholangitis);
4. - damage to the structure of the bile ducts;
5. - disruptions in the functioning of the bile ducts;
6. - for the prevention of liver pathologies caused by toxic medications (antibiotics, cytostatics, Paracetamol and others).

Restrictions on use:

• - any blockage of the bile ducts (adhesions, stones, tumor);
• - inflammatory processes in the walls of the ducts secreting bile (cystic, common bile duct, intrahepatic);
• - acute form of cholecystitis;
• — chronic diseases of the kidneys and pancreas;
• - severe, uncontrolled cirrhosis (stage C, Child-Pugh classification).

Taking Ursosan can cause side effects of a dyspeptic nature:

• - weak stool;
• - attacks of nausea;
• - pain and discomfort in the abdominal area;
• — manifestations of allergic reactions (individual intolerance to the components of the drug) are possible.

Patients with autoimmune diseases may experience a temporary decrease in their overall health. After stopping the medication, your health returns to normal.

Cost of the drug "Ursosan":

• Capsules 10 pieces (250 mg) – 179 rubles;
• Capsules 50 pieces (250 mg) – 864 rubles;
• Capsules 100 pieces (250 mg) – 1479 rubles;
• Film-coated tablets 50 pieces (500 mg) – 1725 rubles;
• Film-coated tablets 100 pieces (500 mg) – 3272 rubles.

Differences between Ursosan and Heptral

Pharmacological effects of drugs:

Taking Heptral does not affect the concentration of cholesterol and the human immune system. In addition, the medicine has no effect on the formation of stones in the bile ducts. It does not have an antidepressant effect.

The drugs are prescribed:

• “Heptral” – for withdrawal symptoms (hangover), as well as for prolonged depression;
• "Ursosan" - for the treatment of gallstone diseases, as well as for the prevention of liver diseases.

These medications have several common indications:

• - stagnation of gastric juice;
• - dysfunction of the biliary tract;
• - cirrhosis;
• - inflammatory process.

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The effect of the drug on the body

A hepatoprotector drug that exhibits choleretic and immunomodulatory effects. The product helps cleanse the liver by removing toxins through the stomach. The drug has a wide range of uses and has the following effects:

• a purifier for the whole body through the gastrointestinal tract;
• immunostimulants;
• normalizes blood flow;
• prevents the formation of cancer cells.

The fact that the product is quite effective can be judged by numerous positive reviews from patients.

The drug is prescribed in the following cases:

• acute forms of hepatitis;
• pathologies of the biliary tract;
• acute alcohol intoxication;
• viral hepatitis.

In all cases, complex treatment is prescribed and one of the drugs is Ursosan. The drug is not suitable for everyone; there are contraindications for use: individual intolerance, cirrhosis, liver failure.

The drug must be taken as prescribed by a doctor; self-medication in this case is not appropriate. The doctor, taking into account the disease and condition of the liver, determines the dose and course of therapy. Treatment is long and can last from six months to two years.

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Based on the instructions for use of Ursosan, it is difficult to determine the compatibility of the drug with alcohol. However, a person suffering from liver problems must eliminate alcohol from his life, otherwise improvement should not be expected.

Action of Nolpaza

The drug is available in enteric-coated tablets. Contains pantoprazole sodium (active ingredient) and additional components. This is a hypoacid medication from the group of proton pump inhibitors. The effect of the main substance is aimed at inhibiting the activity of inflammatory mediators. There is a blockage of hydrophilic secretion of hydrochloric acid in the stomach.

The medicine is used for:

• mild gastroesophageal reflux;
• reflux esophagitis;
• peptic ulcer of the stomach and duodenum;
• hypersecretion of hydrochloric acid;
• damage to the digestive system Helicobacter pylori.

Included in the complex treatment of patients who undergo long-term rehabilitation with the help of non-steroidal anti-inflammatory drugs.

While using medications, patients may develop side symptoms.

This process is accompanied by:

• bowel dysfunction;
• nausea and urge to vomit;
• flatulence and bloating;
• dizziness and headaches;
• weakness;
• visual impairment;
• edema and the development of interstitial nephritis.

Allergic reactions may occur in the form of itching and redness, hives and rashes on the skin.

De-Nol

• Dyspeptic symptoms (nausea, vomiting, constipation or diarrhea);
• Allergic reactions;
• With long-term use, there is a possibility of developing encephalopathy (non-inflammatory brain damage).

Nolpaza

• Allergic reactions;
• Dyspeptic symptoms;
• Headache, insomnia, depression.

Simultaneous use of Ursosan and Heptral

Ursosan and Heptral have different effects, so in practice their combination is acceptable. It is worth noting that the joint prescription of these medications is extremely rare. Most often, treatment is carried out with only one medication. This happens for a number of reasons.

Firstly, the research conducted is not enough to determine all the positive and negative effects of the combined use of Ursosan and Heptral. Modern medicine has not conducted high-quality tests to prove the benefits of using drugs together.

The cost of a full course of treatment with Heptral is 3000-5000 rubles. Ursosan is slightly cheaper, but for most patients it is just as expensive.

Ursosan or Heptral?

Ursosan or Heptral, which is better, doctors' opinion: the medicine "Ursosan" is ideal for pregnant women who have been diagnosed with bile stagnation.

In addition, the medication gives the following effects:

1. — prevents the development of primary biliary cirrhosis;
2. — ensures the destruction of stones in the bile ducts, reduces the risk of their recurrence (by 33%);
3. - the most effective drug for liver diseases that are not associated with alcoholism.

Clinical studies have shown that Heptral significantly makes life easier for patients suffering from stage 1 and stage 2 cirrhosis. In addition, the drug is effective even at the last stage of the disease. During the experiments, no other positive effects were noted that would have been provoked by taking Heptral.

Compatibility and consequences of Ursosan and alcohol

Effective treatment with the drug will only be achieved if bad habits are completely abandoned, including drinking alcohol and following a diet. Otherwise, therapy will be ineffective, and due to progress in the development of pathology, everything will turn into cirrhosis - a disruption of the functioning of the organ.

Even in the case of treatment of alcohol intoxication with the drug, it is necessary to completely abstain from alcohol during treatment and 2-3 days before treatment, in order not to overload the liver. Of course, the process of organ destruction due to the interaction of Ursosan with alcohol occurs in different ways, depending on the individual characteristics of the body and liver damage.

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Alcohol changes organ tissue and this process is inevitable. When combining the drug with alcohol, it is also possible to increase side effects such as:

• pain in the right hypochondrium;
• nausea;
• bowel dysfunction;
• pain in the back and lumbar spine.

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The liver will work at a fast pace, but not efficiently, the release of enzymes increases, and the amount of toxins in the body increases. Due to such failures, the functioning of the entire body is disrupted. Alcohol also slows down the absorption of the drug, which in turn threatens a serious overdose.

Consequences after combining the drug with alcohol:

• bleeding of the gastrointestinal tract;
• increased symptoms of liver disease;
• high risk of overdose;
• the destruction of liver tissue and the entire organ accelerates.

The opinions of all specialists are similar - theoretically, alcohol makes liver treatment meaningless, this should be clear to even the most distant people from medical concepts. The statistics of deaths from alcohol destruction are simply sad and are getting higher every year.

How to combine

It is not recommended to take alcohol and medication at the same time; this can lead to complications and overdose.

Even low-alcohol beer and Ursosan are not recommended for combination by doctors, due to the high risk of deterioration of health and the approaching state of liver decay.

When can you drink

Regarding drinking alcohol after a course of treatment, this is a difficult question, since Ursosan is taken in long courses, and after it it is not advisable to return to alcohol. The exception is the early stages of liver disease and not large volumes of alcohol, preferably red wine. In this case, it is necessary to take a break of 7 days between treatment and drinking alcohol.

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A frequent question from patients: when can you drink alcohol after Ursosan? You must remember that you need to wait at least 36 hours after drinking alcohol in order to safely begin treatment with the drug.

Be healthy!

Ursosan and Ursodez, what is the difference

These drugs are generics (drugs with the same active ingredient, marketed under different trade names). But with the same active ingredient, the indications and contraindications for these drugs are different, they also have differences in side effects and release form.

Indications

Ursosan:

• For the prevention and treatment of cholelithiasis;
• Acute hepatitis (inflammation of liver tissue), of various origins;
• Cirrhosis (replacement of healthy connective tissue) of the liver;
• Liver damage as a result of exposure to alcohol, toxins;
• Stagnation of bile in the ducts.

Ursodez:

• Bile reflux into the stomach (biliary reflux - gastritis);
• Sclerosis (replacement of healthy tissue, scar tissue) of the bile ducts in the liver;
• Impaired flow of bile;
• Cholelithiasis;
• Alcoholic cirrhosis of the liver;
• Liver damage from toxins.