Motilium for gastritis - help in improving general condition

Motilium is an effective drug for the full treatment of various diseases of the gastrointestinal tract, which helps to quickly stimulate intestinal motility.

This medication has pronounced antiemetic and antispasmodic effects, which can effectively eliminate pain in the epigastric (epigastric) region of the abdomen.

The main active ingredient is Domperidone, which helps normalize the digestive process in a fairly short time.

As a rule, this drug is prescribed in complex treatment (simultaneously with other drugs) of various gastrointestinal disorders of the digestive process.

Main indications for the use of Motilium:

• indigestion;
• heartburn;
• frequent or periodic pain in the epigastric (epigastric) region of the abdomen;
• gastroesophageal reflux;
• esophagitis (feeling of fullness in the epigastrium);
• flatulence;
• nausea or vomiting of various origins;
• complex treatment of regurgitation syndrome;
• belching;
• violation of digestive motility in children;
• diarrhea (diarrhea).

Attention: before using Motilium, it is recommended to consult with a qualified gastroenterologist or therapist!

Available in the form of soluble tablets for internal use, as well as suspensions.

Release form

Regardless of the form of release, the medicine contains domperidone as an active substance.
Motilium suspension contains the following additional components: sodium saccharinate, sodium carboxymethylcellulose, methyl parahydroxybenzoate, sodium hydroxide, water, MCC, sorbitol, propyl parahydroxybenzoate, polysorbate.

Excipients of lozenges are gelatin, aspartame, poloxamer 188, mannitol, mint essence.

Coated Motilium tablets contain lactose, microcrystalline cellulose, polyvidone, hydrogenated vegetable oil, hypromelose, corn starch, gelatinized potato starch, magnesium stearate, sodium lauryl sulfate.

The medicine is available in the form of biconvex round tablets of cream or white color. The sides are engraved with "Janssen" and "M/10".

In addition, white instant dissolving tablets and suspension (or syrup) in bottles are sold.

Oral lozenges;

Film-coated tablets for oral administration;

Suspension for oral administration.

Coated and oral tablets are usually called simply “Motilium tablets” without specifying which type we are talking about. And the suspension is often called Motilium syrup in everyday speech. However, since Motilium does not exist in the form of a syrup, people use this term to designate the liquid form of the drug, without going into the subtleties of the differences between suspension, solution, syrup, emulsion, etc. In addition, the suspension is often called children's Motilium, since it is this dosage form that is used in pediatric practice.

All dosage forms of Motilium contain domperidone as an active substance in the following different dosages:

• Oral lozenges – 10 mg;
• Coated tablets for oral administration – 10 mg;
• Suspension – 1 mg per 1 ml.

Auxiliary components of all three dosage forms of Motilium are reflected in the table.

Lozenges are round in shape and colored white or almost white. The coated tablets are round, white or cream-white in color and marked “Janssen” and “M/10” on their flat surfaces. If the coated tablet is broken, then at the break it will be uniformly white, without inclusions. Both types of tablets are available in packs of 10 or 30 pieces.

The suspension is a white, opaque liquid of uniform structure and jelly-like consistency. Available in 100 ml dark glass bottles.

The medicine has 3 release forms:

• round (biconvex) tablets;
• lingual pills are white, round in shape and melt quickly in the mouth;
• suspension in bottles (100, 200 ml).

Packaging - blisters (10, 30 pcs.), cardboard form with 1, 3 blisters per package.

The suspension in bottles is additionally supplied with a measuring pipette (5 ml) or a dosing syringe, graduated cap (10 ml).

One pill contains:

• active ingredient - domperidone (10 mg);
• additional components: povidone, lauryl, lactose sulfate, monohydrate, microcrystalline cellulose, magnesium stearate, cottonseed oil.

The suspension contains, mainly for children (1 ml):

• active ingredient - domperidone (1 mg);
• auxiliary ingredients: microcrystalline cellulose, liquid sorbitol, propyl parahydroxybenzoate, polysorbate, water, sodium hydroxide, sodium saccharinate.

Motilium Motilium suspension

What kind of drug

Motilium is a drug that improves intestinal motor function, has an antiemetic effect, it increases the tone of the sphincter of the lower part of the esophagus. It does not affect the activity of gastric juice and its production.

The active substance of the drug is domperidone (a substance that has antipsychotic properties, but does not have side effects). Taking the drug increases the production of prolactin.

Available in the form of tablets, lozenges and suspension. Each form has different dosages of the active substance and differs in the country of origin.

The most pronounced therapeutic effect is increased peristalsis, which helps accelerate the removal of food from the stomach and duodenum. With rapid evacuation, food does not rot or ferment in the digestive tract, which helps reduce heartburn, nausea and increased gas formation.

Pharmacology

The drug Motilium is an active dopamine antagonist with an antiemetic effect. This is an excellent activator of peristalsis. Conductivity through the circulatory system, the blood-brain barrier, is low.

When taken orally, Motilium promotes:

• acceleration of motility, emptying of gastric contents;
• normalization of bowel movements;
• increased pressure in the lower esophageal sphincter.

Rarely, domperidone leads to extrapyramidal side effects by stimulating the release of prolactin from the pituitary gland. The antiemetic effect is observed due to the peripheral effect on antagonists - dopamine receptors in the trigger receptor zone.

As domperidone is absorbed, no effect on gastric secretion is observed. But for stomach problems, the drug helps improve the passage of solid undigested food.

Motilium has low bioavailability, no more than 15%. When taken on an empty stomach, peak absorption from the gastrointestinal tract into the blood plasma is reached after about 1 hour.

It is advisable to take domperidone 15-20 minutes before meals. Otherwise, due to low acidity in the stomach, the degree of absorption will be reduced. If you take the drug after a meal, the AUC will increase slightly, and it will take much longer to achieve the Cmax effect.

pharmachologic effect

The summary of the drug indicates that it is an antiemetic that activates gastrointestinal motility.

Negative effects are observed only in extremely rare cases.

Anticholinergics may block the action of Motilium. Antifungal drugs of the azole group, HIV protease inhibitors and antibiotics belonging to the macrolide group can inhibit the biotransformation of domperidone and increase its content in the blood plasma, so this combination should be prescribed with caution.

The simultaneous use of Motilium and Ketoconazole in oral form, as well as Erythromycin and strong inhibitors of the CYP3A4 isoenzyme, which cause prolongation of the QT interval, is contraindicated.

It is rare, but it is possible that negative reactions may occur after taking Motilium from one system or another:

• immune can lead to anaphylactic shock, nervous convulsions, extrapyramidal disorders in infants in the first year of life;
• cardiovascular - to ventricular arrhythmia up to sudden coronary death;
• mental - to neuroses, agitation in infants up to one year;
• urinary – to delay, disturbance of urination.

The most common side effects after using Motilium:

• dry mouth;
• sudden cessation of menstruation in women;
• the appearance of convulsions, nervousness, agitation in children;
• Quincke's edema;
• hives;
• gynecomastia, enlarged mammary glands in men.

After using the drug, children experience: diarrhea, asthenia, itching of the skin, drowsiness. Women often experience swelling of the mammary glands, discharge of serous discharge, drowsiness, amenorrhea, galactorrhea, decreased libido, and depression.

During laboratory tests, an increased level of prolactin in the blood and kidney dysfunction are observed.

Motilium is a stimulant of intestinal motility and is inappropriate for use in conjunction with antacid, antisecretory drugs to avoid reducing the absorption of Domperidone.

Macrolides, antibiotics, and antimycotics will help inhibit the initial metabolism of domperidone, although a maximum increase (almost 3 times) in AUC is observed in the plateau phase.

If Domperidone is taken in combination with Ketoconazole, the duration of the QT interval will be slightly increased.

It is acceptable to use Motilium with dopaminergic receptor agonists (Bromocript, Levodopa) and the therapeutic effect will not change. It is possible to reduce the bioavailability of Motilium when taken together or previously with sodium bicarbonate (Cimetidine).

Domperidone is metabolized mainly by the CYP3A4 isoenzyme. Other drugs that inhibit these enzymes may lead to increased plasma concentrations of domperidone.

These are antifungals (Fluconazole), antibiotics (Clarithromycin), protease inhibitors (Saquinavir), calcium antagonists (Amiodarone, Verapamil).

What we combine Motilium with - first of all:

• neuroleptics;
• dopamine receptor antagonists without affecting the vomiting center.

Thanks to the active component in the composition, Motilium quickly blocks neurotransmitter receptors, due to which the excitatory effect is transmitted to the vomiting center along the nerve endings.

This mechanism of action eliminates the connection between the vomiting center and the stomach, leading to the suppression of vomiting and nausea.

By increasing the tone of the lower esophageal sphincter, alcohol has a blocking effect on dopamine antagonists and reduces the effect of Motilium itself.

Its use becomes simply impractical.

If a healthy person who does not suffer from a chronic disease drinks an excessive dose of alcohol, then a protective mechanism will work and the anti-nausea reflex will quickly remove excess poison from the body.

In the case of hangover syndrome and alcohol withdrawal, the development of chronic alcoholism in patients is possible. But it should not be confused with signs of ordinary intoxication due to an alcohol overdose. In the case of absystemic syndrome, metabolism begins to suffer.

To properly support the functionality of the brain during a hangover, the patient will want to drink another dose of alcohol in order to bring the functioning of the internal organs back to normal.

Failure to receive the next dose of alcohol will lead to headaches, hand tremors, increased nausea and vomiting. If you abruptly stop drinking, psychosis, delirium tremens, and alcoholic delirium may occur.

Withdrawal syndrome is treated with Motilium in order to minimize vomiting and nausea. The recommended dose is 20 mg up to 4 times a day shortly before meals. The maximum dose should not exceed 8 tablets per day.

Side effects

Clinical study data:

• Side effects observed in ≥1% of patients who took Motilium: anxiety, depression, headache, lack of or decreased libido, akathisia, drowsiness, diarrhea, rash, itching, dry mouth, gynecomastia, galactorrhea, amenorrhea, menstrual irregularities , asthenia, lactation disorders, sensitivity and pain in the mammary glands;
• Side effects observed in <1% of patients taking Motilium: urticaria, hypersensitivity, breast swelling and discharge.

Spontaneous reports of adverse reactions:

• Cardiovascular system: very rarely - ventricular arrhythmia, QT interval prolongation, sudden coronary death;
• Kidneys and urinary tract: very rarely - urinary retention;
• Nervous system: very rarely - seizures, extrapyramidal disorders (mainly in children and infants);
• Mental health: very rarely – nervousness, agitation (mainly in children and infants);
• Immune system: very rarely - anaphylactic reactions (including anaphylactic shock);
• Laboratory indicators: very rarely - increased blood prolactin levels, deviations in liver function tests;
• Skin and subcutaneous tissues: very rarely - urticaria, Quincke's edema.

Indications for use

Indications for the use of Motilium: vomiting, hiccups, nausea, atony and hypotension, cholecystitis, reflux esophagitis, peptic ulcers, the need to accelerate peristalsis before X-ray studies of the gastrointestinal tract, biliary dyskinesia, cholangitis, flatulence.

As a component of complex treatment, the drug is taken for exacerbation of gastric and duodenal ulcers.

Indications for the use of Motilium for children: gastroesophageal reflux, cyclic vomiting, regurgitation syndrome.

The medicine has the following contraindications:

• bleeding in the gastrointestinal tract, perforation, mechanical obstruction;
• prolactinoma;
• negative reaction of the body to the components of the drug;
• severe or moderate liver dysfunction.

The drug should be taken with caution in case of kidney dysfunction, as well as cardiac rhythm and conduction disorders.

It is advisable to consult a specialist about possible contraindications to the use of the medicine.

Relief of the following symptoms of gastric hypotension, gastritis, GERD, reflux esophagitis, gastroesophageal reflux, resulting from food retention in the stomach and its slow evacuation into the intestine:

• Feeling of heaviness, pressure, or fullness in the stomach after eating;
• Pain in the stomach after eating;
• Bloating;
• Flatulence;
• Belching, including sour contents;
• Nausea;
• Vomit;
• Heartburn;
• Regurgitation (reflux of a fairly large amount of stomach contents into the oral cavity).

Nausea or vomiting caused by infectious diseases, pathologies of any internal organs, or functional disorders (for example, errors in diet,

, eating too much food at once, etc.).

Nausea and vomiting caused by medications, radiotherapy and

tumors.

Nausea and vomiting caused by taking Levodopa

or other dopamine agonist drugs for parkinsonism.

Relief of nausea and gag reflex during medical procedures, for example, insertion of a gastric tube, production of endoscopy, etc.

Regurgitation syndrome in children.

Cyclic vomiting in children.

Gastric motility disorders in children.

Motilium perfectly eliminates belching, acid reflux, bloating, and a feeling of fullness in the stomach. If you are worried about nausea and vomiting, you can take a pill once or complete a full course of treatment.

It should be used with caution in patients with heart disease, as there is a high likelihood of side effects.

Nausea and vomiting, regardless of origin (infectious, organic, functional), can be caused by:

• diet violation;
• non-compliance with dosages during drug therapy;
• radiotherapy, chemotherapy.

The medicine quickly evacuates food into the duodenum and leads to muscle activation.

Indications for use:

• flatulence;
• vomit;
• epigastric pain;
• belching;
• pain in the epigastric region;
• dyspepsia in children;
• heartburn with stomach contents;
• nausea as Parkinson's disease progresses;
• feeling of fullness in the stomach;
• slowness of gastric emptying;
• reflux esophagitis;
• congestion of the esophagus against the background of an inflammatory process;
• bloating;
• indigestion;
• biliary dyskinesia;
• digestive system failure;
• hypotension and atony;
• frequent regurgitation syndrome;
• cyclic vomiting in children;
• hiccups;
• atony, hypotension, peptic ulcer;
• paralytic ileus due to hernial intestinal obstruction;
• unspecified cholecystitis;
• esophageal ulcer;
• cholelithiasis;
• stones in the gallbladder ducts;
• abnormal movement of food, gastric contents through the esophagus in children or in the opposite direction.

Motilium eliminates gagging and heartburn when contents reflux into the esophagus. If a burning sensation occurs, then you should not resort to taking baking soda. It is enough to take a tablet of the drug, and your health will quickly return to normal.

Heartburn and diarrhea are common problems in overweight people who abuse medications, smoking and alcohol. If diarrhea is caused by an intestinal infection (salmonella), then the drug will relieve the problem and normalize your well-being.

It is forbidden to take Motilium if:

• liver dysfunction in severe cases;
• perforation of the rectum;
• prolactinoma;
• increased levels of prolactin in the blood;
• intestinal obstruction;
• perforation of the ulcer;
• intestinal perforation;
• liver diseases;
• heart failure, cardiac dysfunction in the prolonged QT interval;
• passing black stools due to gastric bleeding;
• tumors of the secreting pituitary gland.

Concomitant use with Ketoconazole, Fluconazole, Amiodarone, Voriconazole, Erythromycin, and other potent inhibitors of the CYP3A4 isoenzyme is prohibited.

Motilium requires careful use in case of heart disease, detection of kidney dysfunction, also in combination with Domperidone in pregnant and lactating women, in particular elderly people over 60 years of age. It is necessary to reduce doses.

On a note! Despite the popularity of the drug, it should not be taken without taking into account contraindications, in particular for children. You should first consult your doctor.

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Motilium for gastritis - help in improving general condition

Motilium can be used for inflammatory diseases of the stomach, which are accompanied by impaired tone and peristalsis of the gastrointestinal tract. This leads to food retention in the stomach and causes such unpleasant symptoms as a feeling of fullness in the stomach, pain, nausea and vomiting. Motilium helps improve the patient's condition.

Motilium for acute gastritis

Acute gastritis is an inflammation of the gastric mucosa caused by exposure to some short-term factor - infection, toxic substance, drug, rough, spicy and poor-quality food, and so on. All these factors have an irritating effect on the gastric mucosa, causing inflammation. This leads to disruption of the secretion of gastric juice, the digestion process, and a decrease in the tone and peristalsis of the smooth muscles of the stomach. Food is digested slowly, lingers in the stomach, and the products of its incomplete digestion irritate the mucous membrane. That is, acute gastritis is characterized by a violation of the secretory and motor functions of the stomach.

Symptoms of acute gastritis are nausea, vomiting, and abdominal pain. If the cause of gastritis is an infection, then a high temperature appears, intoxication and dehydration increase.

Treatment for gastritis depends on the cause that caused it. For example, in case of poisoning, gastric lavage is performed, in case of bacterial infection, antibacterial drugs are prescribed, and so on. For any type of acute gastritis, large amounts of fluid are prescribed to prevent dehydration.

In addition, for the treatment of acute gastritis, medications are prescribed that stimulate the motor activity of the stomach, which promote the evacuation of food from the stomach and its movement through the gastrointestinal tract. These drugs include motilium, the mechanism of action of which is associated with blocking the transmission of the neurotransmitter dopamine to nerve cell receptors. The main task of dopamine is to “deliver information” about the state of the stomach to the central nervous system (CNS), including the vomiting center. And if there is no information about trouble, the vomiting center does not cause phenomena such as nausea and vomiting - when motilium is prescribed, they are suppressed.

Motilium also causes an increase in tone and increased peristalsis of the smooth muscles of the stomach - the stomach quickly empties and food passes into the duodenum. This greatly alleviates the patient's condition.

Motilium for chronic gastritis

Chronic gastritis is a chronic inflammatory process in the gastric mucosa, which is characterized by alternating exacerbations and clear intervals and ends, as a rule, with atrophic changes (decrease in volume) in the mucous membrane. The cause of chronic gastritis can be nutritional disorders, severe physical and neuropsychic stress, constant stress, prolonged use of medications or foods that irritate the stomach, food allergies, exposure to a bacterial infection (Helicobacter pylori) and so on.

All manifestations of chronic gastritis, as well as acute ones, are caused by a violation of the secretory and motor functions of the stomach. When the disease worsens, pain appears in the upper abdomen, often of a paroxysmal nature, heartburn, belching, and constipation. In addition, digestive disorders are accompanied by such general disorders as weakness, decreased performance, general malaise, headaches, and so on.

When treating chronic gastritis, a complex treatment is prescribed, the composition of which may vary depending on the type and stage of gastritis, and the patient’s condition. But an obligatory component in this case are prokinetic drugs that increase the tone and motor activity of the smooth muscles of the gastrointestinal tract and promote the rapid evacuation of food from the stomach. Prokinetics are prescribed both during exacerbation and during remission as anti-relapse treatment.

One of the prokinetics is motilium, the mechanism of action of which is associated with blocking dopamine receptors. The use of motilium during an exacerbation of chronic gastritis as part of complex treatment promotes the rapid disappearance of the main symptoms of the disease and accelerates the onset of remission. As an anti-relapse treatment, motilium can be used either alone or together with other medications that reduce the risk of exacerbations.

The course of treatment consists of taking film-coated tablets for oral administration or lingual tablets, one tablet three times a day, half an hour before meals. The duration of the course of treatment is determined by the doctor.

Motilium for gastritis should be prescribed by a doctor.

Galina Romanenko

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Pharmacodynamics and pharmacokinetics

The medicine inhibits dopamine receptors. This property, in combination with the gastrokinetic effect, determines the antiemetic effect of the drug.

When used internally, Motilium increases the pressure of the lower esophageal sphincter, accelerates gastric emptying and helps improve antroduodenal motility.

After taking on an empty stomach, the active substance of the drug is absorbed from the gastrointestinal tract in a short time. The degree of absorption of domperidone decreases due to a decrease in the acidity of gastric juice. The maximum plasma concentration is observed after approximately 0.5-1 hour. In people with moderate liver dysfunction it can be 1.5 times higher than in healthy people.

Absolute bioavailability is about 15%. When using the medicine after meals, the maximum concentration is reached later. In healthy people, bioavailability increases when taken after meals. If you have problems with the gastrointestinal tract, you should use the drug 15-30 minutes before meals.

The degree of binding of the active substance to plasma proteins is 91-93%. Once in the body, it undergoes rapid and active biotransformation in the liver through hydroxylation and N-dealkylation.

The drug is excreted 31% in urine and 66% in feces. About 11% of the active substance is excreted unchanged.

The plasma half-life after a single dose is 7-9 hours. In people with severe renal impairment, the half-life increases to 20.8 hours and plasma concentrations decrease. Only about 1% is excreted unchanged through the kidneys. In people with impaired liver function, the half-life is 15-23 hours.

Instructions for use

It is possible to use the medicine in tablets and suspensions.

The tablet form is taken immediately 2 hours before meals or in the morning on an empty stomach.

If taken after a meal, the absorption of domperidone from the stomach may be significantly delayed.

If the acidity of the stomach is low, it is better to take the drug in tablets 40 minutes before meals.

The maximum dose per day is 80 mg. For adults and adolescents over 12 years old - 1 pill 4 times a day.

An acceptable dose for children is 1 pill 4 times. If there is no effect, then the daily dose may be increased to 80 mg.

On a note! When used in children under 5 years of age, it is extremely important to consider weight. The recommended form for infants is a suspension, for children weighing more than 35 kg - a tablet form of the medicine.

Suspension dosage based on body weight for children:

• infants up to 1 year - 0.5 ml;
• 3-4 years - 2.2 ml;
• up to 12 years - 2.4 ml.

The maximum dosage of the suspension per day should not exceed 2.4 mg per 1 kg of weight.

If incessant vomiting resolves, then an increase in dose to 20 mg up to 4 times a day is indicated.

It is important to take lozenges correctly. It is not recommended to force them through the foil due to their excessive fragility.

Necessary:

• carefully remove the cell from the tablet;
• extract;
• put under the tongue;
• wait 2-3 seconds until completely dissolved;
• swallow with saliva, without water.

For liver and kidney dysfunction, it is recommended to reduce the dose by more than 2 times. If the manifestations of the pathology are minor, then there is no need to adjust the dose.

The bottle must be shaken before use.

Further:

• press your finger on the top of the lid;
• make a counterclockwise turn;
• remove the cover;
• remove the pipette from the case;
• fill the pipette with the contents, holding the lower ring with one hand;
• give the medicine, put it on the tongue;
• rinse the pipette with clean water;
• close the bottle and store.

Cases of overdose with Motilium are rare.

If you do not follow the dosage and doctor’s recommendations, you may experience:

• disorientation in space;
• extrapyramidal reaction;
• lethargy, drowsiness.

Attention! The occurrence of adverse reactions should be a reason to discontinue the drug and consult a doctor. You also need to rinse the stomach with a weak solution of potassium permanganate, drink activated charcoal, an antihistamine or anticholinergic agent.

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The instructions for use of Motilium indicate that the dosage regimen may vary depending on whether the tablets or suspension are used in each specific case.

In case of chronic dyspepsia, adults need to take the medicine 10 mg (1 tablet) on an empty stomach 3 times a day. If necessary, you can use the drug before bedtime. For those who use Motilium suspension and tablets, the instructions for use do not recommend exceeding the daily dosage of 80 mg.

Children are given syrup in a dosage of 2.5 ml of medicine per 10 kg of weight. This should be done 3 times a day on an empty stomach. If necessary, take the medicine before bedtime.

Instructions for use of Motilium for children over 1 year of age also indicate that, if necessary, the dose can be increased by 2 times. The maximum dosage per day is 2.4 mg/kg, but not more than 80 mg.

In case of nausea and vomiting, take syrup in a dosage of 20 ml or 2 tablets. This should be done 3-4 times a day on an empty stomach and before bedtime. Daily dosage – no more than 80 mg.

Suspension for children is given at the rate of 5 ml of product per 10 kg of weight. The medicine is taken 3-4 times a day on an empty stomach and before bedtime. The maximum daily dosage is 2.4 mg/kg, but not more than 80 mg.

Tablets can only be given to adults and children weighing over 35 kg. If your body weight is less, you need to use the so-called children's Motilium in the form of syrup.

Before use, the bottle of suspension must be shaken well. To open it, you need to press on the plastic cover and turn it. Next, remove the cap containing the Motilium suspension; the instructions for use indicate that it should only be drawn up using a special pipette that comes with the drug.

Overdose symptoms: drowsiness, extrapyramidal reactions, disorientation.

There is no special antidote. In case of overdose, it is advisable to rinse the patient’s stomach and give activated carbon. It is necessary to monitor the patient's condition and carry out supportive measures.

In case of extrapyramidal reactions, anticholinergic and antihistamine drugs may be effective.

Motilium tablets - how to take if you have a disorder? Instructions, analogues

Poor nutrition, side effects from taking medications, constant stress, the consequences of alcohol abuse - all this inevitably leads to gastrointestinal disorders. This condition is accompanied by unpleasant symptoms and leads to the development of diseases of the digestive system. In this case, Motilium tablets come to the rescue, the properties and indications for use of which we will consider in this article.

Properties of the drug and general information

In case of poisoning and severe upset of the gastrointestinal tract, both vomiting and diarrhea can occur, so taking a medicine called Motilium is an excellent treatment. Motilium
is an antiemetic drug that has the property of blocking dopamine receptors. Due to the active ingredient domperidone, which is part of the drug, the drug improves gastrointestinal motility, therefore it is used in the treatment of many gastric pathologies.

Motilium is available in the form of a suspension, which is also called “Motilium syrup”, as well as in the form of coated tablets and lozenges.

Instructions for use describe the following properties of Motilium:

• Suppresses the activity of the vomiting center in the brain;
• Increases pressure in the esophagus;
• Increases the duration and intensity of contractions of the duodenum and stomach;
• Accelerates the evacuation of food lumps from the stomach into the duodenum.

Such properties determine the therapeutic effect of the drug - relief of symptoms of digestive disorders (belching, heartburn, vomiting, nausea, feeling of heaviness, etc.) associated with gastric pathologies, in which food stagnates in the stomach.

Important! For patients suffering from gastric pathologies, Motilium is prescribed to relieve symptoms of digestive system disorders.

The substance domperidone stimulates the contractile activity of the gastric muscles, resulting in the rapid evacuation of lumps of food into the duodenum. Food does not stagnate in the stomach and does not irritate it, so a person quickly goes away the unpleasant symptoms of dyspepsia. Thus, Motilium helps to nullify the manifestations of stomach diseases in which food stagnates (peptic ulcer, gastritis, gastric hypotension, etc.).

Healthy people may also experience symptoms of digestive disorders, for example, due to poor diet, overeating, alcohol abuse, etc. In this case, the drug helps to cope with the unpleasant sensations of fullness in the stomach.

By suppressing the vomiting center in the brain, Motilium eliminates vomiting, which can be caused by taking medications, an infectious disease, digestive disorders due to poor nutrition, or other similar factors.

When is Motilium used?

Motilium is effective in combating symptoms such as vomiting, heartburn, severe indigestion, heaviness in the stomach and many others.
Indications for use for all forms of Motilium (suspension, tablets) are the same:

1. Relief of symptoms arising from gastritis, reflux esophagitis, gastric hypotension, gastroesophageal reflux:

• Flatulence;
• Vomit;
• Belching;
• Bloating;
• Heartburn;
• Feelings of heaviness, fullness, pressure in the stomach after eating.

1. Vomiting and nausea caused by pathologies, infectious diseases or conditions that arise from motion sickness, poor diet, or overeating.
2. Vomiting and nausea resulting from taking certain medications, chemotherapy, and radiotherapy.
3. Vomiting and nausea accompanying certain medical procedures (for example, insertion of a gastric tube).
4. Gastric motility disorders.
5. Regurgitation syndrome in a newborn baby.

For children

Indications for the use of Motilium in children are due to conditions such as bloating, difficulty emptying, gastrointestinal reflux, and cyclic vomiting.

Important! Motilium quickly relieves the unpleasant symptoms that arise from poisoning in a baby, promotes the speedy restoration of disturbed processes and speeds up recovery.

Typically, children are prescribed the drug in the form of a suspension, because it is more convenient for a child to take.

During pregnancy

Motilium helps the expectant mother to establish intestinal motility in the early and late stages of pregnancy.

Motilium relieves unpleasant manifestations of gestosis and toxicosis - nausea, vomiting, impaired motor function of the gastrointestinal tract.

During the postpartum period, Motilium can be prescribed as indicated by doctors to stimulate the secretion of breast milk.

For nausea

Motilium's instructions initially describe the drug as an antiemetic. To prevent nausea, the drug is best taken on an empty stomach or at least two hours before meals.

If you have motion sickness, Motilium can be taken half an hour before your planned trip.

For heartburn

The feeling of heartburn occurs due to the accumulation of stomach contents in the esophagus. This condition can occur after suffering stress, due to poor nutrition, alcohol abuse, obesity, or an unbalanced diet.

Motilium quickly relieves the unpleasant symptom, but it will not be able to get rid of heartburn forever if you do not simultaneously improve your diet and get rid of bad habits.

For diarrhea

Diarrhea usually appears due to a malfunction of the intestines due to bacterial infections or food poisoning.

Most often, diarrhea affects children who put objects into their mouths that may be contaminated with salmonella, as well as tourists who like to eat exotic food.

Motilium will help improve intestinal function by eliminating diarrhea within a short period of time.

How to take Motilium

When taking tablets, you must strictly follow the indicated daily dose, otherwise in case of an overdose, the symptoms that were there before will only intensify and others will be added to them.
Motilium tablets are taken before meals - usually 15-30 minutes before. If necessary, the drug can also be taken before bed.

The coated tablets are swallowed with a sufficient amount of water. Lozenges are placed under the tongue and waited until it turns into small particles, after which you can simply swallow them or drink about half a glass of water.

To eliminate the symptoms of dyspepsia, the drug is taken according to the scheme - 1 tablet three times a day (for children over five years of age and adults). If necessary, the dosage can be doubled (two tablets), and this dose can only be given to children from the age of 12.

To relieve nausea and vomiting, two tablets are prescribed three to four times a day for adults and children over 12 years of age. If the age is from 5 to 12 years, one tablet of the drug is also given three or four times a day.

Maximum daily dosage:

• ¼ tablet (2.4 mg) per kilogram of weight for ages 5-12 years, but not more than 80 mg per day.
• No more than 8 tablets per day for adolescents over 12 years of age and adults.
• 2.5 ml per 10 kg of weight for children under 5 years of age (daily dose is calculated individually).

Note! For children under 5 years of age and weighing less than 35 kg, Motilium is prohibited for use.

Exceeding the daily dose and prolonged uncontrolled use of the medicine can provoke an overdose:

• Lethargy, weakness, drowsiness;
• Impaired motor activity;
• Excitement, changes in consciousness;
• Changes in muscle tone (muscle twitching or immobility in children).

If such symptoms appear, you should immediately consult a doctor who will prescribe antihistamines, sorbents and cleansers.

The use of Motilium is prohibited for the following diseases and conditions:

• Gastrointestinal bleeding;
• Prolactinoma;
• Concomitant use of drugs containing erythromycin, ketoconazole, clarithromycin, amiodarone, erythromycin, voriconazole, telithromycin;
• Epilepsy;
• Mechanical intestinal obstruction;
• Individual sensitivity to components;
• Glaucoma;
• Mammary cancer;
• Perforation of any organ of the gastrointestinal tract.

In some cases, both types of Motilium tablets and suspension can cause side effects:

• Constipation or diarrhea, dry mouth, intestinal spasms;
• Convulsions, muscle tone disorders, speech disorders, headache, drowsiness;
• Nervousness or excitement;
• Allergic reactions;
• Rashes, itching.

In women, the use of the drug can cause absence of menstruation, in men - bi- or unilateral enlargement of the male mammary glands.

Analogs and reviews

Motilium analogues use the same active ingredient, so if for some reason Motilium is not suitable, then you can safely look towards both more expensive and cheaper analogues.
The price of Motilium tablets is about 400 rubles. for a package of 10 pieces, and about 700 rubles. per pack of 30 tablets.

If there are contraindications for Motilium, or a person is not satisfied with how much the drug costs, cheaper substitutes can be used.

Analogues (from 40 to 180 rubles):

• Domperidone;
• Cerucal;
• Perinorm;
• Dimetpramide;
• Cerulgan;
• Metoclopramide.

The use of Motilium in adults and children in most cases has positive reviews, but there are also mixed opinions, because the drug has been used by people for various conditions and diseases.

Thus, when taking a drug to eliminate vomiting and nausea, 2/3 of the reviews note the immediate effect of the drug after the first pill taken. But 1/3 of the patients noted long-term use of pills, i.e. the result did not appear immediately, which forced people to leave negative comments.

When using Motilium to relieve symptoms accompanying pathologies of the stomach and intestines, a rapid effect was observed, so reviews of Motilium in this case are almost 100% positive.

Any disturbance of the digestive system is a reason to consult a doctor. You should not decide to take Motilium on your own, especially if it concerns diseases of the digestive system.

Home » Diseases » Motilium tablets - how to take if you have a disorder? Instructions, analogues

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During pregnancy (and lactation)

It is acceptable to use Motilium for women during pregnancy if the benefit is significantly higher in contrast to the potential harm to the fetus. But the drug can have a negative effect on infants.

The level of domperidone in the blood will not exceed the norm, although excoriation of up to 7 mcg per day into breast milk is permissible. The total concentration of the active ingredient in breast milk can reach 50%.

An inadequate reaction from the endocrine glands may occur, which will lead to increased secretion of human milk, menstrual irregularities, soreness of the mammary glands, and increased secretion of prolactin.

There is little evidence about whether Motilium can provoke abnormal development in children and nursing mothers. Potential risks have not been proven. However, it is not recommended to take the drug in the 1st trimester of pregnancy (12 - 14 weeks).

It is better for women during breastfeeding to stop taking the drug or consult a specialist about a possible replacement with a gentle analogue.

There is insufficient data on the effect of the drug during pregnancy. There is no information about the risk to the fetus. However, it is advisable to allow the drug during pregnancy only if the benefit of treatment is greater than the potential threat to the fetus.

When breastfeeding, the concentration of the active substance of the drug is 10-50% of its level in the blood plasma. It is not known whether the drug has negative effects on newborns. Taking the drug is also possible only if the benefit to the mother is greater than the possible risk to the baby.

Contraindications and adverse reactions

Despite the great benefits of the antidiarrheal drug, not everyone is allowed to use it for the stomach. Thus, Motilium is not recommended for patients with individual intolerance to any component of its composition. In addition, the medication is prohibited in case of obstruction of the digestive canal, gastrointestinal bleeding, as well as in the case of erosions and ulcerative lesions of the stomach.

PAY ATTENTION! Do not prolong gastritis or an ulcer until stomach cancer, it is better to be on the safe side, but this will be necessary. read the story of Galina Savina >>

According to the instructions, Motilium is contraindicated for use by persons who have been diagnosed with glaucoma, epilepsy and malignant tumors in the mammary glands. It should be noted that the medicine cannot be used if there is lactose intolerance or the process of glucose absorption is impaired. It is necessary for women carrying a child and nursing mothers to give up Motilium. With extreme caution, it is allowed to use the medicine in patients whose kidney and liver function is impaired.

In most cases, Motilium is well tolerated and no side symptoms are noted while taking it. But occasionally, undesirable effects such as:

• headache;
• convulsions;
• nervousness;
• drowsiness;
• anaphylactic shock;
• allergic reactions;
• hives;
• absence of menstruation.

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Use in childhood

Neurological disorders in children after 5 years of age from taking Motilium are rare.

In infants under 1 year of age, due to an incompletely formed metabolism, dyspeptic disorders may appear against the background of an overdose, and the risks of neuralgia are much higher.

When using Motilium for children, it is extremely important to calculate exact dosages and take into account weight.

Especially for infants in the first year of life with a body weight of less than 35 kg.

The preferred dose for children under 3 years of age is a suspension, after 5 years of age - a lingual form of tablets under the tongue.

Important! Motilium is good at eliminating vomiting and nausea; it can be used for regurgitation in babies, but it is extremely important to follow the dosage. The maximum dosage should not exceed 80 mg per day.

Acceptable doses:

• up to 5 years – suspension, 500 mg per 1 kg of weight before meals and before bedtime up to 4 times a day;
• up to 12 years - 10 mg 4 times a day;
• after 12 years 20 mg - 3-4 times a day.

The main thing is to monitor the body’s reaction after using Motilium for children and monitor their general well-being. It is not recommended to ignore adverse reactions. You need to urgently stop the drug and contact your pediatrician.

The syrup should be used only with the permission of a doctor. It is advisable to take the medicine at the same time. If you miss a dose, drink a portion at any time and adjust the treatment process.

If you are worried about severe heartburn, you can take the suspension 0.5 hours before meals.

Contraindications

Motilium has side effects that make it impossible to take in the following conditions:

• period of gestation and breastfeeding;
• internal bleeding (stomach or intestinal);
• complete or partial intestinal obstruction;
• malignant neoplasm in the brain;
• pheochromacytoma;
• epilepsy;
• oncological processes in the breast area;
• increased intraocular pressure (glaucoma);
• personal intolerance to the components that make up Motilium.

If an allergic reaction occurs or your health worsens after taking it, you should stop further treatment with the drug and consult your doctor for advice and selection of another drug.

Important. Persons with serious liver dysfunction should take this drug only under strict medical supervision and in a hospital setting.

Use for renal impairment

Motilium should be taken with extreme caution in case of liver failure due to increased metabolism of Domperidone in liver cells.

If the patient suffers from renal failure, then it is necessary to increase the time interval between doses of Motilium. Excretion of the drug unchanged by the kidneys occurs in small quantities. There is no need to adjust the single dose for patients.

For renal colic, the dosage and frequency of doses should be reduced. Take Motilium no more than 2 times a day. In severe cases with severe kidney damage, it is possible to reduce the dose by an additional 1.5-2 times.

Antisecretory agents

These pills reduce the amount of gastric juice because they block histamine receptors. The most common medications from this group are Ranitidine, Gastrocepin, Cimetidine.

This category includes proton pump inhibitors, which reduce acid secretion. Most often from this group, patients are prescribed Omeprazole, Pariet.

Ranitidine

Helps reduce the production of hydrochloric acid, improves blood microcirculation. It can be prescribed for treatment and prevention if a person has a predisposition to the disease. Ranitidine is usually taken twice a day.

Gastrocepin

This is an M1-cholinergic receptor blocker, the action is aimed at suppressing the production of gastric juice, as well as protecting the mucous membrane from an aggressive alkaline environment. Gastrocepin is prescribed for high acidity to reduce the amount of gastric juice secreted. You need to take the tablets 2 times a day.

Cimetidine

This drug reduces acidity levels and makes acid production less intense. You can take the tablets right before meals for 6 weeks.

special instructions

It is undesirable to take Motilium together with antisecretory and antacid medications.

It is better to divide and take after meals, Motilium - before meals.

The drug in lingual tablets containing lactose should not be taken by patients with excessive galactosemia, impaired absorption of glucose, galactose.

Caution is required in case of liver failure.

In case of kidney damage, dosage adjustment is not required, since the percentage of active Motilium particles excreted by the urinary system is insignificant.

Taking into account the severity of renal failure, it is possible to reduce the dosage by 2-3 times. If long-term therapy is prescribed, it should be carried out under the strict supervision of doctors. When using the drug for infants, it is important for mothers to monitor the reaction after each dose of Motilium.

Overdose

If the medication is used correctly, an overdose is unlikely. However, if you neglect the doctor’s prescriptions and exceed the recommended doses, then intoxication of the body with the medicinal substances of Motilium will occur, which manifests itself in the form of convulsions, disorientation, increased drowsiness and extrapyramidal reactions. The medicine does not have a specific antidote, so in case of overdose it is necessary to carry out symptomatic treatment, which includes gastric lavage and taking activated charcoal. In addition, the victim is required to undergo electrocardiography.

Gastritis is usually accompanied by unpleasant symptoms, among which unpleasant symptoms such as bloating, nausea, and vomiting take almost the first place. When treating this disease, special attention is paid to ridding a person of these signs that interfere with leading a full life. In this matter, a medicine such as Motilium has come to the aid of doctors.

This drug helps relieve the patient of severe symptoms of gastritis, which are associated with disruption of the gastrointestinal tract. Indications for its use are the manifestation of the following signs of the disease:

• Changes in gastric motility, such as the gag reflex and gastroesophageal reflux;
• A state of nausea leading to vomiting, which is caused by dietary disturbances, the body’s reaction to certain medications, or infection of the body;
• Dyspeptic symptoms (heartburn, belching, epigastric pain, bloating and vomiting) associated with gastroesophageal reflux.

The pharmacological effect of Motilium for gastritis is to stimulate intestinal motility. The active ingredient in this drug is domperidone, which is a dopamine antagonist and has the effects of certain antipsychotics.

A medicine such as Motilium, used in the treatment of gastritis to relieve the patient of certain symptoms of the disease, is available in 3 forms - tablets, which are intended for resorption, regular film-coated tablets and suspension (syrup).

The main recommendation when using Motilium for the treatment of gastritis is that this drug, regardless of the release form, should be taken only before meals. Otherwise, the absorption of domperidone may be noticeably slower.

In the case when tablets intended for resorption are prescribed, you should not wash them down with water, since they disintegrate on their own on the tongue within a few seconds.

Special instructions for the use of Motilium for gastritis:

• If antisecretory or antacid drugs are prescribed together with Motilium, they should be taken after meals to avoid combining these drugs;
• The tablets should not be taken by patients with lactose intolerance, as they contain this substance;
• In case of liver failure, this drug is prescribed with caution due to the fact that it has a high degree of metabolism of domperidone in the liver;
• When long-term therapy with this drug is carried out, the patient should be under constant medical supervision.

Conditions for dispensing from pharmacies

The drug is sold in pharmacy chains without a doctor's prescription.

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Motilium price, where to buy

The price of Motilium suspension is on average 540 rubles. This form of release is mainly used for children. The average price of Motilium in lozenges is 530 rubles. You can buy the product in this form of release in many pharmacies; as a rule, it is purchased for adults. In addition, coated tablets are popular. The price of Motilium in this form of release is 620 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Motilium tab. p.o 10 mg n30JANSSEN CILAG
• Motilium Susp. internal 1mg/ml 100ml n1Janssen-Cilag AG
• Motilium express lozenges 10 mg No. 30 Catalent UK Swindon Zaidis Limited/Jansen-Cilag S.p.A.
• Motilium express lozenges 10 mg No. 10 Catalent UK Swindon Zaidis Limited/Jansen-Cilag S.p.A.

Pharmacy Dialogue

• Motilium Express lozenges No. 10
• Motilium bottle 1mg/ml 100ml
• Motilium Express lozenges No. 30
• Motilium tablets 10 mg No. 30

Europharm* 4% discount using promo code medside11

• Motilium suspension 100 mlJanssen Pharmaceuticals N.V. (OTS)
• Motilium tablets 10 mg n30 Janssen-Cilag S.A.
• Motilium express 10 mg No. 30 tablet. for resorptionKatalent UK Swindon Zaidis Limited/Jansen
• Motilium express 10 mg No. 10 tablet. for resorptionKatalent UK Swindon Zaidis Limited/Jansen

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Pharmacy24

• Motilium 10 mg No. 10 tablets Janssen-Cilag S.A., France
• Motilium 10 mg No. 30 tablets Janssen-Cilag S.A., France

PaniPharmacy

• Motilium tablets Motilium tablets. 10mg No. 30 France, Janssen-Cilag
• Motilium tablets Motilium tablets. 10 mg No. 10 France, Janssen-Cilag

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BIOSPHERE

• Motilium 10 mg No. 30 tablet p.o. Janssen-Silag S.A. (France)

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Depending on the form of release of the drug, the average cost is:

• lozenges - 580 rubles;
• suspension in bottles – 560 rubles;
• tablets in a lingual coating - 630 rubles. This is the most popular form of use for adults.

Reviews about Motilium

Reviews of Motilium characterize the drug as a highly effective, fast-acting remedy. It is very popular among consumers. Reviews of Motilium for children are also mostly positive. This remedy is often recommended by pediatricians, but not for infants. In the latter case, the effect of the drug has not been studied. In addition, the medicine is rarely used by nursing mothers, since its harm to lactation has not been studied.

Among the negative aspects, those who took Motilium note only a slightly inflated cost.

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